HbA(1c) and birthweight in women with pre-conception type 1 and type 2 diabetes: a population-based cohort study

Diabetologia. 2012 Dec;55(12):3193-203. doi: 10.1007/s00125-012-2721-z. Epub 2012 Sep 27.

Abstract

Aims/hypothesis: To investigate clinical and sociodemographic predictors of birthweight in singletons born to women with type 1 or type 2 diabetes.

Methods: Normally formed singleton live births and intrapartum stillbirths, born to women with pre-conception diabetes during 1996-2008, were identified from the population-based Northern Diabetes in Pregnancy Survey (n = 1,505). Associations between potential predictors and birthweight were analysed by multiple regression.

Results: Potentially modifiable independent predictors of increase in birthweight were pre-pregnancy care (adjusted regression coefficient [b] = 87.1 g; 95% CI 12.9, 161.3), increasing third-trimester HbA(1c) ≤7% (53 mmol/mol) (b = 310.5 g per 1% [11 mmol/mol]; 95% CI 246.3, 374.7) and increasing maternal BMI (b = 9.5 g per 1 kg/m(2); 95% CI 3.5, 15.5). Smoking during pregnancy (b = -145.1 g; 95% CI -231.4, -58.8), later gestation at first antenatal visit (b = -15.0 g; 95% CI -26.9, -3.0) and higher peri-conception HbA(1c) (b = -48.2 g; 95% CI -68.8, -27.6) were independently associated with birthweight reduction. Pre-pregnancy nephropathy (b = -282.7 g; 95% CI -461.8, -103.6) and retinopathy (b = -175.5 g; 95% CI -269.9, -81.0) were independent non-modifiable predictors of reduced birthweight, while greater maternal height was a non-modifiable predictor of increasing birthweight (b = 17.8 g; 95% CI 12.3, 23.2). Other predictors of birthweight increase were male sex, multiparity and increasing gestational age at delivery. Type or duration of diabetes, socioeconomic status and ethnicity were not associated with continuous birthweight.

Conclusions/interpretation: Poor glycaemic control before and throughout pregnancy is associated with abnormal fetal growth, with increasing peri-conception HbA(1c) predicting weight reduction and increasing third-trimester HbA(1c) predicting increased birthweight. Women with microvascular complications of diabetes may require increased surveillance to detect fetal growth restriction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Birth Weight
  • Cohort Studies
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / epidemiology*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Female
  • Fetal Growth Retardation / blood
  • Fetal Growth Retardation / epidemiology*
  • Fetal Macrosomia / blood
  • Fetal Macrosomia / epidemiology*
  • Glycated Hemoglobin A* / metabolism
  • Humans
  • Infant, Newborn
  • Maternal Age
  • Pregnancy
  • Pregnancy Trimester, Third
  • Pregnancy in Diabetics / blood
  • Pregnancy in Diabetics / epidemiology*
  • Smoking / adverse effects
  • Smoking / epidemiology
  • United Kingdom / epidemiology

Substances

  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human