Synthesis of 2,6-disubstituted tetrahydroazulene derivatives

Beilstein J Org Chem. 2012:8:693-8. doi: 10.3762/bjoc.8.77. Epub 2012 May 4.


Synthesis of hydroazulene derivatives has been carried out through a ring-enlargement route by using carbene adduct intermediates. The protocol can be applied for the construction of functionalized hydroazulene skeletons as key components of many natural products as well as the core system of novel liquid-crystalline materials.

Keywords: carbene addition; hydroazulenes; liquid crystals; ring expansion.