Emergence of intense suicidal preoccupation during fluoxetine treatment

Am J Psychiatry. 1990 Feb;147(2):207-10. doi: 10.1176/ajp.147.2.207.


Six depressed patients free of recent serious suicidal ideation developed intense, violent suicidal preoccupation after 2-7 weeks of fluoxetine treatment. This state persisted for as little as 3 days to as long as 3 months after discontinuation of fluoxetine. None of these patients had ever experienced a similar state during treatment with any other psychotropic drug.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Depressive Disorder / drug therapy
  • Female
  • Fluoxetine / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Monoamine Oxidase Inhibitors / therapeutic use
  • Suicide*
  • Time Factors


  • Monoamine Oxidase Inhibitors
  • Fluoxetine