Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected]

Am J Transplant. 2013 Jan;13(1):36-44. doi: 10.1111/j.1600-6143.2012.04283.x. Epub 2012 Sep 27.


Leptin, an adipose-secreted hormone, links metabolism and immunity. Our aim was to determine whether leptin affects the alloimmune response. We used an allogeneic skin transplant model as a means to analyze the allograft immune response in Lep(ob/ob) and wild-type mice. Leptin deficiency results in an increased frequency of Treg and Th2 cells and a prolonged graft survival. These effects of leptin deficiency indicate the importance of leptin and obesity in modulating the allograft immune responses. Our data suggest a possible explanation for the increased susceptibility of hyperleptinemic obese patients to acute and chronic graft rejection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Flow Cytometry
  • Graft Survival / physiology*
  • Leptin / physiology*
  • Lymphocyte Culture Test, Mixed
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Polymerase Chain Reaction
  • Th2 Cells / immunology*
  • Transplantation, Homologous


  • Leptin