Relaxin-3 is associated with metabolic syndrome and its component traits in women

Clin Biochem. 2013 Jan;46(1-2):45-8. doi: 10.1016/j.clinbiochem.2012.09.018. Epub 2012 Sep 24.


Objectives: Relaxin-3 was found to play a role in appetite regulation, increasing food intake and body weight. The current study aimed to investigate the relation of relaxin-3 to metabolic syndrome and its component traits in women.

Design and methods: The study was conducted on 300 female subjects, 150 healthy control and 150 metabolic syndrome patients. The component traits of metabolic syndrome were determined for all participants.

Results: Serum relaxin-3 level was significantly higher in the metabolic syndrome patients than in the healthy control group. It was also significantly correlated with all the component traits of metabolic syndrome.

Conclusion: The results suggest that metabolic syndrome is associated with increased serum relaxin-3 levels in women. Relaxin-3 might be considered as a potential biomarker of metabolic syndrome.

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Blood Pressure
  • Body Mass Index
  • Case-Control Studies
  • Female
  • Humans
  • Lipids / blood
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / etiology*
  • Predictive Value of Tests
  • ROC Curve
  • Relaxin / blood*


  • Blood Glucose
  • Lipids
  • RLN3 protein, human
  • Relaxin