Soluble trail as a marker of efficacy of allergen-specific immunotherapy in patients with allergic rhinoconjunctivitis

Med Sci Monit. 2012 Oct;18(10):CR617-21. doi: 10.12659/msm.883488.


Background: Allergic rhinitis is a common health problem affecting the immune system. The homeostasis of the immune system is regulated by apoptosis. In this study, serum circulating soluble TRAIL levels of allergic rhinoconjunctivitis patients before and after allergen-specific immunotherapy were evaluated.

Material/methods: The sTRAIL levels of pre- and post-treated allergic rhinoconjunctivitis patients (n=25) were compared to age- and sex-matched healthy individuals (n=25). sTRAIL levels were measured by ELISA. The skin prick test (SPT) results were recorded before and after treatment.

Results: The sTRAIL levels between the pre-treated and control groups were significantly different (p<0.0001). However, there was no significant difference between the post-treated group and healthy individuals (p=0,801). SPT was a statistically significant difference between the values of the research group before and after immunotherapy (grasses mixture, barley mixture, Oleaauropeae, D. Pteronyssinus, D. farinae).

Conclusions: The sTRAIL levels were decreased after allergen-specific immunotherapy to healthy levels and may be of use as a marker of efficacy of immunotherapy in allergic rhinoconjunctivitis patients.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Case-Control Studies
  • Conjunctivitis / blood*
  • Conjunctivitis / complications
  • Conjunctivitis / immunology
  • Conjunctivitis / therapy*
  • Demography
  • Desensitization, Immunologic*
  • Female
  • Humans
  • Male
  • Rhinitis, Allergic, Seasonal / blood*
  • Rhinitis, Allergic, Seasonal / complications
  • Rhinitis, Allergic, Seasonal / immunology
  • Rhinitis, Allergic, Seasonal / therapy*
  • Skin Tests
  • Solubility
  • TNF-Related Apoptosis-Inducing Ligand / blood*
  • Treatment Outcome


  • Biomarkers
  • TNF-Related Apoptosis-Inducing Ligand