Antimicrobials: Strategies for Targeting Obesity and Metabolic Health?

Gut Microbes. Jan-Feb 2013;4(1):48-53. doi: 10.4161/gmic.22328. Epub 2012 Sep 27.

Abstract

Obesity is associated with a number of serious health consequences, including type 2 diabetes, cardiovascular disease and a variety of cancers among others and has been repeatedly shown to be associated with a higher risk of mortality. The relatively recent discovery that the composition and metabolic activity of the gut microbiota may affect the risk of developing obesity and related disorders has led to an explosion of interest in this distinct research field. A corollary of these findings would suggest that modulation of gut microbial populations can have beneficial effects with respect to controlling obesity. In this addendum, we summarize our recent data, showing that therapeutic manipulation of the microbiota using different antimicrobial strategies may be a useful approach for the management of obesity and metabolic conditions. In addition, we will explore some of the mechanisms that may contribute to microbiota-induced susceptibility to obesity and metabolic diseases.

Keywords: antimicrobials; firmicutes; gut microbiota; metabolic disease; obesity.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage*
  • Bacteria / classification
  • Bacteria / drug effects*
  • Disease Models, Animal
  • Gastrointestinal Tract / microbiology*
  • Mice
  • Obesity / microbiology
  • Obesity / prevention & control*

Substances

  • Anti-Bacterial Agents