Five-year follow-up of helium ion therapy for uveal melanoma

Arch Ophthalmol. 1990 Feb;108(2):209-14. doi: 10.1001/archopht.1990.01070040061031.


One hundred sixty-four patients with uveal melanoma were treated with helium ion irradiation prior to May 1984, and the data were analyzed in June 1989. Most uveal melanomas were large, with a mean tumor thickness of 6.5 mm; approximately 60% of the patients had tumors that extended anterior to the equator. A complete follow-up was obtained for all patients. One hundred twelve patients were alive at the time of this report; 18% of the patients developed clinical and laboratory evidence of metastases and eventually died of widespread tumor. Eighty-four percent of eyes were retained. Data were analyzed with a number of parametric and nonparametric techniques. Larger tumors and those located in close proximity to the optic nerve and fovea had a higher incidence of most complications, especially visual loss.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cataract / etiology
  • Evaluation Studies as Topic
  • Eye Enucleation
  • Female
  • Follow-Up Studies
  • Glaucoma, Neovascular / etiology
  • Helium / therapeutic use*
  • Humans
  • Male
  • Melanoma / complications
  • Melanoma / pathology
  • Melanoma / radiotherapy*
  • Melanoma / secondary
  • Middle Aged
  • Prognosis
  • Radioisotopes / therapeutic use*
  • Uveal Neoplasms / complications
  • Uveal Neoplasms / pathology
  • Uveal Neoplasms / radiotherapy*
  • Visual Acuity


  • Radioisotopes
  • Helium