Dermatopathology updates on melanocytic lesions

Dermatol Clin. 2012 Oct;30(4):617-22, vi. doi: 10.1016/j.det.2012.06.014. Epub 2012 Aug 3.


This article provides an update on histopathologic studies of different types of melanocytic lesions, such as site-specific nevi, "Spark's" nevi, nevi during pregnancy, and atypical dermal melanocytic proliferation, including pigmented epithelioid melanocytoma, proliferating nodules, and atypical Spitzoid tumor. Special-site nevi, such as those appearing on the breast and genital region, generally have more cytologic and architectural atypia. Melanocytic proliferations generally do not change during pregnancy, contrary to earlier observations. Atypical dermal melanocytic proliferations are difficult to diagnose and usually have a better outcome after adequate treatment, including wide local skin excision with or without sentinel lymph node resection.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / pathology*
  • Dysplastic Nevus Syndrome / pathology*
  • Extremities
  • Female
  • Head and Neck Neoplasms / pathology*
  • Humans
  • Melanocytes / pathology
  • Nevus, Epithelioid and Spindle Cell / pathology
  • Nevus, Pigmented / pathology*
  • Pregnancy
  • Pregnancy Complications, Neoplastic / pathology*
  • Skin Neoplasms / pathology*
  • Torso
  • Vulvar Neoplasms / pathology*