Current status and future directions in appendiceal cancer with peritoneal dissemination

Surg Oncol Clin N Am. 2012 Oct;21(4):599-609. doi: 10.1016/j.soc.2012.07.012.


This article focuses on the use of intraperitoneal hyperthermic chemotherapy for the treatment of peritoneal dissemination from appendiceal primary tumors. The first part of the article details patient selection criteria used at the Wake Forest University School of Medicine and the use of preoperative imaging and endoscopic evaluation in the management of this cohort of patients. The second part of the article focuses on clinical outcomes for patients undergoing hyperthermic intraperitoneal perfusion for peritoneal dissemination from appendiceal tumors. Finally, future challenges for the use of hyperthermic intraperitoneal perfusion for appendiceal primary tumors are explored.

Publication types

  • Review

MeSH terms

  • Appendiceal Neoplasms / drug therapy
  • Appendiceal Neoplasms / pathology*
  • Appendiceal Neoplasms / surgery
  • Carcinoma / drug therapy
  • Carcinoma / secondary*
  • Carcinoma / surgery
  • Chemotherapy, Cancer, Regional Perfusion / adverse effects
  • Chemotherapy, Cancer, Regional Perfusion / methods*
  • Humans
  • Hyperthermia, Induced / methods*
  • Peritoneal Neoplasms / drug therapy
  • Peritoneal Neoplasms / secondary*
  • Peritoneal Neoplasms / surgery
  • Preoperative Care