Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 204 (1), 1-12

The Prefrontal Cortex Influence Over Subcortical and Limbic Regions Governs Antidepressant Response by N=H/(M+R)

Affiliations
Review

The Prefrontal Cortex Influence Over Subcortical and Limbic Regions Governs Antidepressant Response by N=H/(M+R)

Alen Johannes Salerian et al. Psychiatry Res.

Abstract

We review the evidence for relationships between metabolic activity of cortical, subcortical and limbic brain regions in depression and the efficacy of antidepressant agents. The influence of these regions can be described by an algebraic equation, N=H/(M+R), where N represents a homeostatic level of executive function, H represents prefrontal (Brodmann areas 9, 10, 11, 12; 46) and cingulate cortex activity (24, 25; 32), M represents subcortical (hippocampus, parahippocampal gyrus) influences, and R represents limbic (amygdala) influences. This hypothesis is based on depressed prefrontal cortex and enhanced amygdala and hippocampal metabolism in major depressive disorder, and the remission of these changes by most antidepressant interventions. The therapeutic efficacy of antidepressant strategies may depend less on their presumptive molecular mechanisms of action and more on their ability to restore the predominant metabolic and executive functions of the prefrontal cortex, and dampen excessive subcortical and limbic influences.

Similar articles

See all similar articles

Cited by 5 articles

Publication types

MeSH terms

Substances

LinkOut - more resources

Feedback