Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes

FEBS Lett. 2012 Nov 2;586(21):3771-7. doi: 10.1016/j.febslet.2012.09.026. Epub 2012 Sep 26.

Abstract

PARP enzymes influence the immune system at several key points and thus modulate inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and regulate the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase and adhesion molecules. Moreover, PARP enzymes are key regulators of cell death during inflammation-related oxidative and nitrosative stress. Here we provide an overview of the different inflammatory diseases regulated by PARP enzymes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / metabolism
  • Cell Death
  • Cell Differentiation
  • Cytokines / genetics
  • Cytokines / immunology
  • Gene Expression
  • Humans
  • Inflammation / enzymology*
  • Inflammation / genetics
  • Inflammation / immunology
  • Mice
  • Nitric Oxide Synthase Type II / genetics
  • Nitric Oxide Synthase Type II / metabolism
  • Oxidative Stress
  • Poly(ADP-ribose) Polymerases / genetics
  • Poly(ADP-ribose) Polymerases / metabolism*
  • Signal Transduction / genetics*
  • T-Lymphocytes / cytology
  • T-Lymphocytes / enzymology
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Cell Adhesion Molecules
  • Cytokines
  • Transcription Factors
  • Nitric Oxide Synthase Type II
  • Poly(ADP-ribose) Polymerases