Chronotherapeutics--a chronopharmaceutical approach to drug delivery in the treatment of asthma

J Control Release. 2012 Nov 10;163(3):353-60. doi: 10.1016/j.jconrel.2012.09.012. Epub 2012 Sep 27.


Bronchial asthma is a chronic inflammatory disorder of the airways associated with airflow obstruction that is reversible spontaneously or with treatment. Bronchial asthma is a disease based on established circadian rhythm. The symptoms of asthma worsen during midnight to early morning and therefore it is required to deliver the drug in such fashion that effective treatment can be obtained during the time of asthma attacks. Chronotherapy is an approach that fulfills the criteria of drug delivery at a specific time as per the pathophysiological need of the disease, to improve patient compliance. The current article focuses on the chronotherapy of bronchial asthma, methodologies involved for the existing systems, recent updates and different chronopharmaceutical technologies currently available in the market. Chronotherapy with different categories of bronchial asthma medications also has been reviewed.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-2 Receptor Antagonists / administration & dosage
  • Anti-Asthmatic Agents / administration & dosage*
  • Asthma / drug therapy*
  • Drug Chronotherapy*
  • Glucocorticoids / administration & dosage
  • Humans
  • Leukotriene Antagonists / administration & dosage
  • Theophylline / administration & dosage


  • Adrenergic beta-2 Receptor Antagonists
  • Anti-Asthmatic Agents
  • Glucocorticoids
  • Leukotriene Antagonists
  • Theophylline