Supramolecular metal displacement allows on-fluorescence analysis of manganese(II) in living cells

Chem Commun (Camb). 2012 Nov 11;48(87):10778-80. doi: 10.1039/c2cc34742c.


Due to the importance of Mn(2+) ions in biological processes, it is of growing interest to develop protocols for analysis of Mn(2+) uptake and distribution in cells. A supramolecular metal displacement assay can provide ratiometric fluorescence detection of Mn(2+), allowing for quantitative and longitudinal analysis of Mn(2+) uptake in living cells.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cadmium / chemistry*
  • Cell Line
  • Cell Survival
  • Fluorescence*
  • Fluorescent Dyes / chemistry*
  • HEK293 Cells
  • Humans
  • Macromolecular Substances / chemistry
  • Magnesium / analysis*
  • Magnesium / pharmacokinetics


  • Fluorescent Dyes
  • Macromolecular Substances
  • Cadmium
  • Magnesium