Differences in sensitivity to neuroleptic blockade: medial forebrain bundle versus frontal cortex self-stimulation

Behav Brain Res. 1990 Jan 1;36(1-2):91-6. doi: 10.1016/0166-4328(90)90163-9.


The effects of systemic injections of the dopamine receptor antagonist, cis-flupenthixol were tested on intracranial self-stimulation at electrode sites in the medial forebrain bundle and the medial prefrontal cortex. Changes in the reward effectiveness of the brain stimulation were assessed using a curve-shift paradigm. Low to moderate doses of cis-flupenthixol (0.05, 0.1 and 0.15 mg/kg) consistently produced larger upward shifts in the rate-frequency function for medial forebrain bundle than for medial prefrontal self-stimulation. At the highest doses of cis-flupenthixol (0.15 and 0.2 mg/kg), some of the medial forebrain bundle rats failed to respond, whereas all medial prefrontal rats responded at these doses. These results demonstrate that medial forebrain bundle self-stimulation is much more dependent on dopamine systems than is prefrontal cortex self-stimulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arousal / drug effects
  • Dopamine / physiology*
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • Flupenthixol / pharmacology*
  • Frontal Lobe / drug effects*
  • Male
  • Medial Forebrain Bundle / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / drug effects*
  • Self Stimulation / drug effects*
  • Thioxanthenes / pharmacology*


  • Receptors, Dopamine
  • Thioxanthenes
  • Flupenthixol
  • Dopamine