Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4

Nat Genet. 2012 Nov;44(11):1231-5. doi: 10.1038/ng.2424. Epub 2012 Sep 30.

Abstract

Prostate cancer risk-associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk-associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this study identified two new risk-associated loci for prostate cancer on chromosomes 9q31.2 (rs817826, P = 5.45 × 10(-14)) and 19q13.4 (rs103294, P = 5.34 × 10(-16)) in 4,484 prostate cancer cases and 8,934 controls. The rs103294 marker at 19q13.4 is in strong linkage equilibrium with a 6.7-kb germline deletion that removes the first six of seven exons in LILRA3, a gene regulating inflammatory response, and was significantly associated with the mRNA expression of LILRA3 in T cells (P < 1 × 10(-4)). These findings may advance the understanding of genetic susceptibility to prostate cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian Continental Ancestry Group
  • Chromosomes, Human, Pair 19
  • Chromosomes, Human, Pair 9
  • DNA Repair Enzymes / genetics
  • DNA-Binding Proteins / genetics
  • Gene Deletion
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study*
  • Humans
  • Kruppel-Like Transcription Factors / genetics
  • Male
  • Polymorphism, Single Nucleotide
  • Prostatic Neoplasms / genetics*
  • Receptors, Immunologic / genetics*
  • Risk Factors

Substances

  • DNA-Binding Proteins
  • GKLF protein
  • Kruppel-Like Transcription Factors
  • LILRA3 protein, human
  • RAD23B protein, human
  • Receptors, Immunologic
  • DNA Repair Enzymes