Prevalence of group B Streptococcus colonization in subsequent pregnancies of group B Streptococcus-colonized versus noncolonized women

Am J Perinatol. 2013 May;30(5):383-8. doi: 10.1055/s-0032-1326981. Epub 2012 Sep 21.


Objective: To determine whether group B Streptococcus (GBS)-colonized pregnant women have an increased prevalence of GBS colonization in subsequent pregnancies.

Study design: This retrospective cohort study compared the prevalence of GBS colonization in initial and subsequent pregnancies of 158 women with two or more deliveries at a Midwest institution since the initiation of universal screening for GBS.

Results: The GBS colonization rate in index pregnancies was 20%. Colonization rate in subsequent pregnancies for initially GBS-colonized women was 42% compared with 19% for women who were not colonized with GBS in the index pregnancy (p = 0.009). The relative risk for GBS-colonized women to be GBS-colonized in subsequent pregnancies was 2.2 (confidence interval = 1.3 to 3.8).

Conclusion: Previous GBS colonization is a risk factor for GBS colonization in subsequent pregnancies. Consideration of intrapartum chemoprophylaxis in women with a history of GBS colonization, assuming current colonization status is unknown, warrants further investigation.

MeSH terms

  • Adult
  • Cohort Studies
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications, Infectious / epidemiology*
  • Prevalence
  • Rectum / microbiology
  • Recurrence
  • Retrospective Studies
  • Streptococcal Infections / epidemiology*
  • Streptococcus agalactiae*
  • Vagina / microbiology
  • Young Adult