Abstract
Biological macromolecules can be encapsulated into preformed polymersomes by controlled temporary destabilization of the vesicle membrane. The morphology and the size of the polymersome are unchanged after electroporation, suggesting that the polymersome membrane is reformed. The surface charge of the biomacromolecules plays a key role for the electroporation process.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
MeSH terms
-
Animals
-
Cattle
-
DNA / chemistry
-
Electroporation*
-
HEK293 Cells
-
Humans
-
Immunoglobulin G / chemistry
-
Macromolecular Substances / chemistry
-
Methacrylates / chemistry*
-
Muramidase / chemistry
-
Muramidase / metabolism
-
Myoglobin / chemistry
-
Phosphorylcholine / analogs & derivatives*
-
Phosphorylcholine / chemistry
-
Polymethacrylic Acids / chemistry*
-
RNA, Small Interfering / chemistry
-
Serum Albumin, Bovine / chemistry
Substances
-
Immunoglobulin G
-
Macromolecular Substances
-
Methacrylates
-
Myoglobin
-
Polymethacrylic Acids
-
RNA, Small Interfering
-
poly(2-(diisopropylamino)ethyl methacrylate)
-
poly(2-methacryloyloxyethyl-phosphorylcholine)
-
Phosphorylcholine
-
Serum Albumin, Bovine
-
DNA
-
Muramidase