Soluble CD14 subtype (sCD14-ST) presepsin in critically ill preterm newborns: preliminary reference ranges

J Matern Fetal Neonatal Med. 2012 Oct;25(Suppl 5):51-3. doi: 10.3109/14767058.2012.717462.


Soluble CD14 subtype (sCD14-ST), also named presepsin, is a 13 kDa truncated form of soluble CD14 (sCD14), consisting of 64 amino acid residues. Systemic inflammation and sepsis are characterized by an early, significant increase in sCD14-ST presepsin blood concentration and thus, this small polypeptide has been proposed as a novel, reliable biomarker for the management of sepsis. We enrolled twenty-six consecutive non-septic preterm newborns with gestational age (GA) between 26 and 36 weeks) admitted to NICU after the first day of life for various severe diseases. sCD14-ST presepsin was measure on whole blood samples by a rapid commercial available chemiluminescent enzyme immunoassay (CLEIA) based on a non-competitive CLEIA. The mean sCD14-ST presepsin blood level in 26 preterm newborns was 643.1 ng/L, with a standard deviation (SD) of 303.8 ng/L; the median value was 578 ng/L. Our results clearly suggest no correlation between GA and sCD14-ST presepsin blood level between 26 and 36 weeks and thus it is reasonable to adopt a unique reference range for preterm newborns.

MeSH terms

  • Female
  • Gestational Age*
  • Humans
  • Immunoenzyme Techniques
  • Infant, Newborn
  • Infant, Premature*
  • Infant, Premature, Diseases / blood*
  • Inflammation / blood
  • Intensive Care, Neonatal
  • Lipopolysaccharide Receptors / blood*
  • Luminescent Measurements
  • Male
  • Prognosis
  • Reference Values
  • Sepsis / blood


  • Lipopolysaccharide Receptors