Increased thiamine intake may be required to maintain thiamine status during weight loss in patients with type 2 diabetes

Diabetes Res Clin Pract. 2012 Dec;98(3):e40-2. doi: 10.1016/j.diabres.2012.09.032. Epub 2012 Sep 29.

Abstract

During weight loss, erythrocyte thiamine pyrophosphate (TPP) decreased (221±52 to 195±39 nmol/L, P<0.05) on a diet with adequate thiamine (1.1 mg/day) but was unchanged (217±55 vs 218±52 nmol/L, NS) on a high thiamine diet (2.8 mg/day). Attention to thiamine status may be required in patients with diabetes after weight loss.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / complications*
  • Diet, Reducing / adverse effects*
  • Dietary Proteins / administration & dosage
  • Erythrocytes / metabolism
  • Female
  • Food, Fortified / analysis
  • Humans
  • Intention to Treat Analysis
  • Male
  • Meat / analysis
  • Middle Aged
  • New Zealand
  • Obesity / blood
  • Obesity / complications
  • Obesity / diet therapy*
  • Overweight / blood
  • Overweight / complications
  • Overweight / diet therapy*
  • Patient Dropouts
  • Sus scrofa
  • Thiamine / therapeutic use*
  • Thiamine Deficiency / etiology
  • Thiamine Deficiency / prevention & control*
  • Thiamine Pyrophosphate / blood
  • Weight Loss

Substances

  • Dietary Proteins
  • Thiamine Pyrophosphate
  • Thiamine