Angioimmunoblastic T-cell lymphoma mice model

Leuk Res. 2013 Jan;37(1):21-7. doi: 10.1016/j.leukres.2012.09.009. Epub 2012 Sep 29.


We established an angioimmunoblastic T-cell lymphoma (AITL) mouse model using NOD/Shi-scid, IL-2Rγ(null) mice as recipients. The immunohistological findings of the AITL mice were almost identical to those of patients with AITL. In addition, substantial amounts of human immunoglobulin G/A/M were detected in the sera of the AITL mice. This result indicates that AITL tumor cells helped antibody production by B cells or plasma cells. This is the first report of reconstituting follicular helper T (TFH) function in AITL cells in an experimental model, and this is consistent with the theory that TFH cell is the cell of origin of AITL tumor cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA-Binding Proteins / analysis
  • Disease Models, Animal*
  • Humans
  • Immunoblastic Lymphadenopathy / immunology
  • Immunoblastic Lymphadenopathy / pathology*
  • Leukocyte Common Antigens / analysis
  • Lymph Nodes / pathology
  • Lymphoma, T-Cell, Peripheral / immunology
  • Lymphoma, T-Cell, Peripheral / pathology*
  • Mice
  • Mice, Inbred NOD
  • Neoplasm Transplantation
  • Proto-Oncogene Proteins c-bcl-6
  • Transplantation, Heterologous


  • BCL6 protein, human
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins c-bcl-6
  • Leukocyte Common Antigens