Neocortical temporal lobe epilepsy

J Clin Neurophysiol. 2012 Oct;29(5):366-70. doi: 10.1097/WNP.0b013e31826bd78b.


Neocortical temporal lobe epilepsy (NTLE) comprises a heterogeneous group of epilepsies with focal seizures characterized by auditory, somatosensory, or psychic auras followed by motionless staring, early contralateral clonic activity often secondarily generalizing. Neurophysiologic findings in NTLE are typically a predominance of lateral temporal interictal epileptiform activity (IEA) and an ictal onset pattern consisting of irregular, hemispheric delta slowing. Advanced neurophysiologic techniques such as EEG and magnetoencephalography source imaging can help to determine the area generating the initial and propagated interictal and ictal activities and may limit the number of patients requiring long-term invasive recordings before epilepsy surgery.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Brain Mapping* / methods
  • Brain Waves*
  • Electroencephalography
  • Epilepsy, Temporal Lobe / diagnosis*
  • Epilepsy, Temporal Lobe / physiopathology
  • Epilepsy, Temporal Lobe / surgery
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Magnetoencephalography
  • Neocortex / pathology
  • Neocortex / physiopathology*
  • Neocortex / surgery
  • Neurosurgical Procedures
  • Periodicity
  • Predictive Value of Tests
  • Temporal Lobe / pathology
  • Temporal Lobe / physiopathology*
  • Temporal Lobe / surgery
  • Treatment Outcome