Dermal Pharmacokinetics of Terpinen-4-ol Following Topical Administration of Zingiber Cassumunar (Plai) Oil

Planta Med. 2012 Nov;78(16):1761-6. doi: 10.1055/s-0032-1315262. Epub 2012 Oct 1.

Abstract

The purpose of this study was to investigate dermal pharmacokinetics of terpinen-4-ol in rats following topical administration of plai oil derived from the rhizomes of Zingiber cassumunar Roxb. Unbound terpinen-4-ol concentrations in dermal tissue were measured by microdialysis. The dermal pharmacokinetic study of terpinen-4-ol was performed under non-occlusive conditions. The oil was topically applied at a dose of 2, 4, and 8 mg/cm2 plai oil corresponding to the amount of 1.0, 1.9, and 3.8 mg/cm2 terpinen-4-ol, respectively. Following topical application of the oil, terpinen-4-ol rapidly distributed into the dermis and demonstrated linear pharmacokinetics with no changes in the dose-normalized area under the concentration-time curves across the investigated dosage range. The mean percentages of free terpinen-4-ol distributed in the dermis per amount of administered were 0.39 ± 0.06 %, 0.41 ± 0.08 %, and 0.30 ± 0.03 % for 2, 4, and 8 mg/cm2 doses, respectively. The dermal pharmacokinetics of terpinen-4-ol could provide information for its further formulation development and therapy schedules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Animals
  • Area Under Curve
  • Dermis / drug effects*
  • Gas Chromatography-Mass Spectrometry
  • Male
  • Microdialysis / methods
  • Plant Oils / administration & dosage*
  • Plant Oils / chemistry
  • Plant Oils / pharmacokinetics
  • Rats
  • Rats, Wistar
  • Rhizome / chemistry
  • Terpenes / administration & dosage
  • Terpenes / chemistry
  • Terpenes / pharmacokinetics*
  • Time Factors
  • Zingiberaceae / chemistry*

Substances

  • Plant Oils
  • Terpenes
  • terpinenol-4