Progeria: translational insights from cell biology

J Cell Biol. 2012 Oct 1;199(1):9-13. doi: 10.1083/jcb.201207072.


Cell biologists love to think outside the box, pursuing many surprising twists and unexpected turns in their quest to unravel the mysteries of how cells work. But can cell biologists think outside the bench? We are certain that they can, and clearly some already do. To encourage more cell biologists to venture into the realm of translational research on a regular basis, we would like to share a handful of the many lessons that we have learned in our effort to develop experimental treatments for Hutchinson-Gilford progeria syndrome (HGPS), an endeavor that many view as a "poster child" for how basic cell biology can be translated to the clinic.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Biology*
  • Humans
  • Lamin Type A / genetics
  • Lamin Type A / metabolism
  • Progeria / drug therapy*
  • Progeria / genetics
  • Progeria / pathology
  • Translational Research, Biomedical*


  • Lamin Type A