Notch signaling

doi:10.1101/cshperspect.a011213

Review

. 2012 Oct 1;4(10):a011213.

doi: 10.1101/cshperspect.a011213.

Notch signaling

Raphael Kopan¹

Affiliations

PMID: 23028119
PMCID: PMC3475170
DOI: 10.1101/cshperspect.a011213

Review

Notch signaling

Raphael Kopan. Cold Spring Harb Perspect Biol. 2012.

. 2012 Oct 1;4(10):a011213.

doi: 10.1101/cshperspect.a011213.

Author

Raphael Kopan¹

Affiliation

¹ Department of Developmental Biology, Washington University, St. Louis, Missouri 63110, USA. kopan@wustl.edu

PMID: 23028119
PMCID: PMC3475170
DOI: 10.1101/cshperspect.a011213

Abstract

When the cell-surface receptor Notch interacts with a ligand (e.g., Delta), its intracellular domain is cleaved and travels to the nucleus to regulate transcription. This influences cell division, fate, and death in metazoans.

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Figures

**Figure 1.**
Notch signaling (simplified view).

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References

1. Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, et al. 2011. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333: 1154–1157 - PMC - PubMed
1. Bozkulak EC, Weinmaster G 2009. Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Mol Cell Biol 29: 5679–5695 - PMC - PubMed
1. Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R 2008. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol 6: e123. - PMC - PubMed
1. Gordon WR, Vardar-Ulu D, L’Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, et al. 2009. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS ONE 4: e6613. - PMC - PubMed
1. Komatsu H, Chao MY, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, et al. 2008. OSM-11 facilitates LIN-12 Notch signaling during C. elegans vulval development. PLoS Biol 6: e196. - PMC - PubMed

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[1] Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, et al. 2011. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333: 1154–1157 - PMC - PubMed

[2] Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, et al. 2011. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333: 1154–1157 - PMC - PubMed

[3] Bozkulak EC, Weinmaster G 2009. Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Mol Cell Biol 29: 5679–5695 - PMC - PubMed

[4] Bozkulak EC, Weinmaster G 2009. Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Mol Cell Biol 29: 5679–5695 - PMC - PubMed

[5] Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R 2008. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol 6: e123. - PMC - PubMed

[6] Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R 2008. Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity. PLoS Biol 6: e123. - PMC - PubMed

[7] Gordon WR, Vardar-Ulu D, L’Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, et al. 2009. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS ONE 4: e6613. - PMC - PubMed

[8] Gordon WR, Vardar-Ulu D, L’Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, et al. 2009. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS ONE 4: e6613. - PMC - PubMed

[9] Komatsu H, Chao MY, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, et al. 2008. OSM-11 facilitates LIN-12 Notch signaling during C. elegans vulval development. PLoS Biol 6: e196. - PMC - PubMed

[10] Komatsu H, Chao MY, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, et al. 2008. OSM-11 facilitates LIN-12 Notch signaling during C. elegans vulval development. PLoS Biol 6: e196. - PMC - PubMed

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Notch signaling

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