JAK Kinases in Health and Disease: An Update

Open Rheumatol J. 2012;6:232-44. doi: 10.2174/1874312901206010232. Epub 2012 Sep 7.


Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. This review will summarize our current knowledge on these key enzymes and their associated pharmaceutical inhibitors.

Keywords: Jak; autoimunity; cancer; cytokine signaling.; kinase inhibitors; myelofibrosis; tyrosine kinase.