The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC

PLoS One. 2012;7(9):e46486. doi: 10.1371/journal.pone.0046486. Epub 2012 Sep 28.

Abstract

p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The Cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / pharmacology
  • Base Sequence
  • Cell Line, Tumor
  • Etoposide / pharmacology
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor*
  • Humans
  • Molecular Sequence Data
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Promoter Regions, Genetic
  • Protein Binding
  • Proto-Oncogene Proteins c-myc / genetics*
  • Proto-Oncogene Proteins c-myc / metabolism
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Transcription, Genetic*

Substances

  • Antineoplastic Agents, Phytogenic
  • MYC protein, human
  • Proto-Oncogene Proteins c-myc
  • SALL2 protein, human
  • Transcription Factors
  • Etoposide