Effectiveness of treatment with surfactant in premature infants with respiratory failure and pulmonary infection

Acta Biomed. 2012:83 Suppl 1:33-6.

Abstract

Introduction: Surfactant inactivation is present in neonatal pneumonia.

Materials and methods: One hundred thirty-nine preterm babies with Birth Weight (BW) < or = 1250 grams were studied and subdivided in two groups: RDS Group, with a diagnosis of "simple" RDS (N 80) and RDS with Pneumonia Group, consisting of babies with a diagnosis of RDS and a positive BALF culture in the first 24-48 h of life (N 59).

Outcomes: Surfactant administration seems less effective in the latter group, because a significantly higher number of infants needed a second dose of surfactant, compared to the patients suffering from RDS alone. (www.actabiomedica.it).

MeSH terms

  • Bronchoalveolar Lavage Fluid / microbiology
  • Escherichia coli Infections / drug therapy
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Intensive Care, Neonatal / methods
  • Male
  • Pneumonia, Bacterial / drug therapy*
  • Pulmonary Surfactants / therapeutic use*
  • Respiratory Distress Syndrome, Newborn / drug therapy*
  • Respiratory Insufficiency / drug therapy*
  • Retrospective Studies
  • Streptococcal Infections / drug therapy
  • Streptococcus agalactiae
  • Treatment Outcome

Substances

  • Pulmonary Surfactants