Predictors of quality of life in patients with refractory mesial temporal lobe epilepsy

Epilepsy Behav. 2012 Oct;25(2):208-13. doi: 10.1016/j.yebeh.2012.06.037. Epub 2012 Sep 30.


Purpose: The identification of variables associated with health-related quality of life (HRQoL) in patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) would improve surgical decision-making and post-operatory follow-up in this group of patients.

Methods: We analyzed the independent association between the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) of 81 consecutive patients with refractory MTLE-HS. The clinical, demographic, radiological and electrophysiological variables were analyzed by multiple linear regression analysis.

Key findings: Approximately 36% (adjusted R(2)=0.36; R coefficient=0.66) of the QOLIE-31 overall score variance was explained by the history of initial precipitant injury, family history of epilepsy, disease duration, age of epilepsy onset, seizure frequency and presence of psychiatric axis-II diagnosis. The variance of QOLIE-31 sub-scales was: seizure worry=7%; overall QOL=11%; emotional well-being=32%; energy/fatigue=38%; cognitive function=13%; medication effects=7%; social function=13% (R coefficient between 0.30 and 0.65).

Significance: The pre-surgical variables studied had relatively low prediction capacity for the overall QOLIE-31 score and its sub-scales in this set of Brazilian patients with refractory MTLE-HS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Epilepsy, Temporal Lobe / pathology
  • Epilepsy, Temporal Lobe / psychology*
  • Epilepsy, Temporal Lobe / surgery
  • Female
  • Health Status
  • Hippocampus / pathology*
  • Hippocampus / surgery
  • Humans
  • Male
  • Quality of Life / psychology*
  • Sclerosis
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Treatment Outcome