Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography

IEEE Trans Med Imaging. 2012 Oct;31(10):1922-8. doi: 10.1109/TMI.2012.2208471.


In many practical optoacoustic imaging implementations, dimensionality of the tomographic problem is commonly reduced into two dimensions or 1-D scanning geometries in order to simplify technical implementation, improve imaging speed or increase signal-to-noise ratio. However, this usually comes at a cost of significantly reduced quality of the tomographic data, out-of-plane image artifacts, and overall loss of image contrast and spatial resolution. Quantitative optoacoustic image reconstruction implies therefore collection of point 3-D (volumetric) data from as many locations around the object as possible. Here, we propose and validate an accurate model-based inversion algorithm for 3-D optoacoustic image reconstruction. Superior performance versus commonly-used backprojection inversion algorithms is showcased by numerical simulations and phantom experiments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Animals
  • Computer Simulation
  • Heart / anatomy & histology
  • Imaging, Three-Dimensional / methods*
  • Mice
  • Models, Theoretical
  • Phantoms, Imaging
  • Photoacoustic Techniques / methods*
  • Tomography / methods*