[First experience of photodynamic diagnosis and laser spectroalanysis in surgery of intracranial meningiomas]

Zh Vopr Neirokhir Im N N Burdenko. 2012;76(4):12-8; discussion 18.
[Article in Russian]


Photodynamic diagnosis (PDD) has been actively implemented into neurooncological practice, especially in cerebral gliomas surgery. This paper describes our first experience of PDD combined with laser spectroanalysis in intracranial meningiomas. The study included 21 patients (8 male and 13 female patients, mean age was 58 years, range--between 37 and 74 years) with intracranial meningiomas operated with PDD in Burdenko Neurosurgical Institute between 2008 and 2011. In 14 cases laser spectroanalysis was used. Tumor fluorescence was present in all but one cases (95%). Spectroanalysis demonstrated that peaks of fluorescence varied between 5 and 46 (mean level was 18.5). These data correlated with visual impression of fluorescence and confirmed that meningioma is a tumor with bright fluorescence. Radical removal (Simpson grade I-II) was achieved in 10 cases, subtotal resection was performed in the rest of the patients. Application of PDD and laser spectroanalysis allows gaining complete information about accumulation of photosensibilizer in the tissue. To our opinion, these methods may be the most useful for determination of the borders of dural and bony invasion which directly affects the surgical tactics and degree of radical removal. Further studies are needed to evaluate the influence of PDD and laser spectroanalysis on long-term surgical outcomes.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Diagnosis, Differential
  • Female
  • Fluorescence
  • Humans
  • Lasers
  • Male
  • Meningeal Neoplasms / diagnosis*
  • Meningeal Neoplasms / surgery
  • Meningioma / diagnosis*
  • Meningioma / surgery
  • Middle Aged
  • Spectrum Analysis