Challenges of Alloimmunization in Patients With Haemoglobinopathies

Br J Haematol. 2012 Nov;159(4):394-404. doi: 10.1111/bjh.12061. Epub 2012 Oct 4.


Red blood cell (RBC) transfusions can be life-sustaining in chronic inherited anaemias, such as thalassaemia, and the indications for blood transfusions in patients with sickle cell disease continue to expand. Complications of transfusions, such as allosensitization, can create significant medical challenges in the management of patients with haemoglobinopathies. This review summarizes key findings from the medical literature related to alloimmunization in haemoglobinopathies and examines potential measures to mitigate these risks. Areas where future studies are needed are also addressed.

Publication types

  • Review

MeSH terms

  • Anemia, Sickle Cell / blood
  • Anemia, Sickle Cell / immunology
  • Anemia, Sickle Cell / therapy
  • Animals
  • Erythrocyte Transfusion / adverse effects*
  • Erythrocytes / immunology
  • Hemoglobinopathies / blood
  • Hemoglobinopathies / immunology*
  • Hemoglobinopathies / therapy
  • Humans
  • Isoantibodies / blood*
  • Prevalence
  • Risk Factors
  • Thalassemia / blood
  • Thalassemia / immunology
  • Thalassemia / therapy


  • Isoantibodies