Efficacy of nasal irrigation in the treatment of acute sinusitis in atopic children

J Microbiol Immunol Infect. 2014 Feb;47(1):63-9. doi: 10.1016/j.jmii.2012.08.018. Epub 2012 Sep 30.


Background: Nasal irrigation has been used as adjunctive therapy for sinonasal disease but is under-researched in children. The study aim was to evaluate the effectiveness of nasal irrigation with normal saline in the management of acute sinusitis in atopic children.

Methods: We enrolled 60 atopic children with acute sinusitis, of whom 29 received nasal irrigation with normal saline and 31 did not receive nasal irrigation. All participants underwent a nasal peak expiratory flow rate (nPEFR) test, a nasal smear examination, and radiography (Water's projection) and were requested to complete a Pediatric Rhinoconjunctivitis Quality-of-Life Questionnaire (PRQLQ) during the baseline visit. All participants were requested to record symptoms in a daily diary and were followed up at 1-week intervals. A physical examination, nasal smear, and nPEFR were performed at each visit, and all daily diaries were collected. At the final visit (after 3 weeks), the symptom diaries were reviewed and participants were requested to complete the PRQLQ again. nPEFR, radiography, and a nasal smear were also repeated.

Results: There were significant improvements in mean PRQLQ and nPEFR values (p < 0.05) for the irrigation compared to the non-irrigation group. There was no significant difference in radiographic findings between the groups (p > 0.05). The irrigation group recorded significant improvements in eye congestion, rhinorrhea, nasal itching, sneezing, and cough symptoms compared with the non-irrigation group.

Conclusion: Nasal irrigation is an effective adjunctive treatment for acute sinusitis in atopic children.

Keywords: Acute sinusitis; Atopic children; Nasal peak expiratory flow rate; Pediatric Rhinoconjunctivitis Quality-of-Life Questionnaire.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Child
  • Child, Preschool
  • Conjunctivitis, Allergic / complications*
  • Female
  • Humans
  • Male
  • Nasal Lavage*
  • Prospective Studies
  • Sinusitis / complications*
  • Sinusitis / therapy*
  • Sodium Chloride / therapeutic use*
  • Treatment Outcome


  • Sodium Chloride