Hippo signaling in mammalian stem cells

Semin Cell Dev Biol. 2012 Sep;23(7):818-26. doi: 10.1016/j.semcdb.2012.08.001. Epub 2012 Aug 8.


Over the past decade, the Hippo signaling cascade has been linked to organ size regulation in mammals. Indeed, modulation of the Hippo pathway can have potent effects on cellular proliferation and/or apoptosis and a deregulation of the pathway often leads to tumor development. Importantly, emerging evidence indicates that the Hippo pathway can modulate its effects on tissue size by the regulation of stem and progenitor cell activity. This role has recently been associated with the central position of the pathway in sensing spatiotemporal or mechanical cues, and translating them into specific cellular outputs. These results provide an attractive model for how the Hippo cascade might sense and transduce cellular 'neighborhood' cues into activation of tissue-specific stem or progenitors cells. A further understanding of this process could allow the development of new therapies for various degenerative diseases and cancers. Here, we review current and emerging data linking Hippo signaling to progenitor cell function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental
  • Humans
  • Mammals
  • Organ Specificity
  • Protein Serine-Threonine Kinases / metabolism
  • Signal Transduction*
  • Stem Cells / metabolism*


  • Protein Serine-Threonine Kinases