Clinical efficacy of a new tooth and tongue gel applied with a tongue cleaner in reducing oral halitosis

Quintessence Int. 2012 Sep;43(8):709-18.


Objective: The short-term and overnight effect of three treatment regimens on oral halitosis were investigated: toothbrushing with a reference toothpaste, toothbrushing with reference toothpaste and tongue cleaning, and toothbrushing and tongue cleaning with a tooth-and-tongue gel.

Method and materials: Fifty-four subjects meeting the inclusion criteria for bad breath were enrolled in the study. All subjects received each of the three treatment regimens in a balanced design. Efficacy was assessed by organoleptic ratings and volatile sulfur compound (VSC) measurements 5 and 60 minutes after first application and overnight after 7 days of repeated use.

Results: The combination of toothbrushing and tongue cleaning with tooth-and-tongue gel provided the best results in terms of organoleptic ratings and VSC measurements at all time points compared to the other treatment regimens.

Conclusion: The use of tooth and tongue gel for both toothbrushing and tongue cleaning showed a positive short-term and overnight effects after 7 days of use. This treatment regimen is a promising approach to control halitosis.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Amines / therapeutic use
  • Cross-Over Studies
  • Dental Devices, Home Care*
  • Dentifrices / therapeutic use*
  • Drug Combinations
  • Female
  • Gels
  • Halitosis / prevention & control*
  • Humans
  • Male
  • Middle Aged
  • Mouthwashes / therapeutic use
  • Statistics, Nonparametric
  • Sulfur Compounds / analysis*
  • Surveys and Questionnaires
  • Tin Fluorides / therapeutic use
  • Tongue* / chemistry
  • Tongue* / microbiology
  • Toothbrushing
  • Young Adult


  • Amines
  • Dentifrices
  • Drug Combinations
  • Gels
  • Mouthwashes
  • Sulfur Compounds
  • Tin Fluorides
  • Meridol