Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus

Clin Vaccine Immunol. 2012 Dec;19(12):1980-3. doi: 10.1128/CVI.00411-12. Epub 2012 Oct 3.


An assay was developed to detect antibodies against two norovirus proteases among participants in a Norwalk virus (GI.1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from a heterologous GII.4 strain. Seroresponses were detected for 14 of 19 (74%) infected persons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Viral / blood*
  • Antibody Formation*
  • Antigens, Viral / immunology*
  • Human Experimentation
  • Humans
  • Immunoassay / methods
  • Norwalk virus / immunology*
  • Peptide Hydrolases / immunology*


  • Antibodies, Viral
  • Antigens, Viral
  • Peptide Hydrolases