Abstract
Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs. Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer's disease drug, binds differently to human AChE than it does to Torpedo AChE. These crystals of human AChE provide a more accurate platform for further drug development than previously available.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acetylcholinesterase / chemistry*
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Acetylcholinesterase / metabolism
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Acetylthiocholine / metabolism
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Animals
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Cholinesterase Inhibitors / metabolism*
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Crystallography, X-Ray
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Donepezil
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Humans
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Indans / metabolism*
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Models, Molecular
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Piperidines / metabolism*
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Protein Conformation
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Torpedo / metabolism*
Substances
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Cholinesterase Inhibitors
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Indans
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Piperidines
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Acetylthiocholine
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Donepezil
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Acetylcholinesterase