Effect of concurrent sucralfate administration on the absorption of erythromycin

J Clin Pharmacol. 1990 Jan;30(1):39-44. doi: 10.1002/j.1552-4604.1990.tb03436.x.

Abstract

To determine the influence of sucralfate on the absorption of erythromycin, prior to evaluating its efficacy in decreasing erythromycin-associated gastrointestinal (GI) intolerance, we assessed pharmacokinetic parameters in six healthy adult volunteers. Erythromycin ethylsuccinate administered alone or with sucralfate as a single dose was compared. Sucralfate did not significantly alter the elimination rate constant, half-life, or area under the curve for erythromycin ethylsuccinate. It is therefore unlikely that efficacy of erythromycin ethylsuccinate will be altered when sucralfate is coadministered.

MeSH terms

  • Adult
  • Drug Interactions
  • Erythromycin / pharmacokinetics*
  • Female
  • Humans
  • Intestinal Absorption
  • Male
  • Sucralfate / pharmacology*

Substances

  • Sucralfate
  • Erythromycin