Surgical treatment for secondary dystonia

Mov Disord. 2012 Nov;27(13):1598-605. doi: 10.1002/mds.25204. Epub 2012 Oct 4.


Surgical therapy for the secondary dystonias is generally perceived to be less effective than for primary disease. However, a number of case reports and small open series have recently appeared describing quite favorable outcomes following surgery for some nonprimary dystonias. We discuss surgical treatment options for this group of diverse conditions, including tardive dystonia, dystonic cerebral palsy, and certain heredodegenerative diseases in which deep brain stimulation and ablative lesions of the posteroventral pallidum have been shown to be effective. Other types of secondary dystonia respond less well to pallidal surgery, particularly when anatomical lesions of the basal ganglia are prominent on preoperative imaging. For these conditions, central baclofen delivery and botulinum toxin denervation may be considered. With optimal medical and surgical care, some patients with secondary dystonia have achieved reductions in disability and pain that approach those documented for primary dystonia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Baclofen / pharmacology
  • Basal Ganglia / drug effects
  • Basal Ganglia / physiology
  • Botulinum Toxins / pharmacology
  • Denervation / methods
  • Dystonic Disorders / therapy*
  • Globus Pallidus / drug effects
  • Globus Pallidus / physiology
  • Humans
  • Neurosurgery / methods*


  • Botulinum Toxins
  • Baclofen