Strategies for engineered negligible senescence

Gerontology. 2013;59(2):183-9. doi: 10.1159/000342197. Epub 2012 Oct 1.


In this viewpoint, we describe the strategies for engineered negligible senescence (SENS) concept--a simple and appealing model for the design of therapeutic interventions able to meaningfully and persistently reverse the deleterious effects of aging. We go on to outline how current or foreseeable biotechnologies could feasibly be employed to repair every currently identified category of pathogenic damage that accumulates over a human lifespan. Then, briefly, we explain why this goal is not only ethically sound, but can in fact be considered to verge on an ethical obligation. Finally, we review recent progress in some key areas of the SENS platform, including proof-of-concept research sponsored by the SENS Foundation, a charity based in California.

MeSH terms

  • Aging*
  • Cell Death
  • Cell Proliferation
  • Cellular Senescence
  • Geriatrics / methods*
  • Humans
  • Models, Biological
  • Regenerative Medicine / methods*