Comparison of analytical performance of two single-step measurement devices of B-type natriuretic Peptide

Int Heart J. 2012;53(5):320-3. doi: 10.1536/ihj.53.320.


Rapid measurement of B-type natriuretic peptide (BNP) plays a practical role in the diagnosis of congestive heart failure. Analytical evaluation of a new small-footprint immunochromatography reader of BNP (Rapidpia®) was performed and compared with the commercially available SHIONOSPOT® Reader as the index. The new BNP assay had a within-run coefficient of variation (CV) of 9.0% and a between-run CV of 2.1%. Correlations between whole blood and plasma samples and those with the index SHIONOSPOT® Reader were y = 0.93x + 0.88, R2 = 0.98 and y = 1.08x - 6.67, R2 = 0.93, respectively. Based on our findings, the two point-of care (POC) assays for BNP, Rapidpia® and SHIONOSPOT® Reader, showed comparable results.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Chromatography / instrumentation*
  • Heart Failure / blood*
  • Heart Failure / diagnosis
  • Humans
  • Natriuretic Peptide, Brain / blood*
  • Point-of-Care Systems
  • Reproducibility of Results


  • Biomarkers
  • Natriuretic Peptide, Brain