An RNA-deaminase conjugate selectively repairs point mutations

Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11166-9. doi: 10.1002/anie.201206489. Epub 2012 Oct 4.

Abstract

Checking for mistakes: By conjugating a catalytic domain with a guide RNA, deamination activity can be harnessed to repair a specific codon on mRNA. This method can be used for the highly selective repair of point mutations in mRNA by site-selective editing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Deaminase / chemistry
  • Adenosine Deaminase / genetics
  • Adenosine Deaminase / metabolism
  • Green Fluorescent Proteins / genetics
  • Humans
  • Models, Molecular
  • Molecular Structure
  • Nucleoside Deaminases / chemistry*
  • Nucleoside Deaminases / genetics
  • Nucleoside Deaminases / metabolism
  • Point Mutation*
  • RNA / chemistry*
  • RNA / genetics
  • RNA / metabolism
  • RNA, Messenger / genetics
  • RNA-Binding Proteins
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • RNA, Messenger
  • RNA-Binding Proteins
  • enhanced green fluorescent protein
  • Green Fluorescent Proteins
  • RNA
  • Nucleoside Deaminases
  • ADARB1 protein, human
  • Adenosine Deaminase