Abstract
Checking for mistakes: By conjugating a catalytic domain with a guide RNA, deamination activity can be harnessed to repair a specific codon on mRNA. This method can be used for the highly selective repair of point mutations in mRNA by site-selective editing.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Deaminase / chemistry
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Adenosine Deaminase / genetics
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Adenosine Deaminase / metabolism
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Green Fluorescent Proteins / genetics
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Humans
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Models, Molecular
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Molecular Structure
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Nucleoside Deaminases / chemistry*
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Nucleoside Deaminases / genetics
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Nucleoside Deaminases / metabolism
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Point Mutation*
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RNA / chemistry*
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RNA / genetics
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RNA / metabolism
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RNA, Messenger / genetics
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RNA-Binding Proteins
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Reverse Transcriptase Polymerase Chain Reaction
Substances
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RNA, Messenger
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RNA-Binding Proteins
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enhanced green fluorescent protein
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Green Fluorescent Proteins
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RNA
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Nucleoside Deaminases
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ADARB1 protein, human
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Adenosine Deaminase