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Review
, 12 (9), 1061-76; quiz 1077

Neurodegeneration in Multiple Sclerosis: Novel Treatment Strategies

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Review

Neurodegeneration in Multiple Sclerosis: Novel Treatment Strategies

Felix Luessi et al. Expert Rev Neurother.

Abstract

In recent years it has become clear that the neuronal compartment already plays an important role early in the pathology of multiple sclerosis (MS). Neuronal injury in the course of chronic neuroinflammation is a key factor in determining long-term disability in patients. Viewing MS as both inflammatory and neurodegenerative has major implications for therapy, with CNS protection and repair needed in addition to controlling inflammation. Here, the authors' review recently elucidated molecular insights into inflammatory neuronal/axonal pathology in MS and discuss the resulting options regarding neuroprotective and regenerative treatment strategies.

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