Post-cardiac injury syndromes. An emerging cause of pericardial diseases

Int J Cardiol. 2013 Sep 30;168(2):648-52. doi: 10.1016/j.ijcard.2012.09.052. Epub 2012 Oct 3.


The term "post-cardiac injury syndromes" includes post-myocardial infarction pericarditis, post-pericardiotomy syndrome, and post-traumatic pericarditis (iatrogenic, i.e. after percutaneous coronary or intracardiac interventions, such as pacemaker lead insertion, radiofrequency ablation, or non-iatrogenic, i.e. following blunt or penetrating trauma). All these conditions represent different clinical conditions characterized by an initial cardiac injury involving the pericardium/myocardium and/or pleura and the subsequent inflammatory syndrome ranging from simple, uncomplicated pericarditis to more complicated cases with pleuropericarditis, cardiac tamponade or massive pleural effusion. The etiopathogenesis is presumed to be immune-mediated in predisposed individuals that develop autoreactive reactions following the initial traumatic event. Treatment is essentially based on empirical anti-inflammatory therapy and adjunctive colchicine, which has been shown to be safe and efficacious for the prevention of pericarditis.

Keywords: Pericarditis; Post-cardiac injury syndrome; Post-pericardial injury syndrome; Post-pericardiotomy syndrome.

Publication types

  • Review

MeSH terms

  • Animals
  • Heart Diseases / diagnosis
  • Heart Diseases / epidemiology
  • Humans
  • Myocardial Infarction / diagnosis*
  • Myocardial Infarction / epidemiology
  • Pericardiectomy / adverse effects
  • Pericardiocentesis / adverse effects
  • Pericarditis / diagnosis*
  • Pericarditis / epidemiology
  • Pericardium / injuries*
  • Pericardium / pathology
  • Pericardium / surgery