Molecular Mechanisms of Mucocutaneous Immunity Against Candida and Staphylococcus Species

J Allergy Clin Immunol. 2012 Nov;130(5):1019-27. doi: 10.1016/j.jaci.2012.09.011. Epub 2012 Oct 3.

Abstract

Signal transducer and activator of transcription (STAT) proteins are key components of the innate and adaptive immune responses to pathogenic microorganisms. Recent research on primary immunodeficiency disorders and the identification of patients carrying germline mutations in STAT1, STAT3, and STAT5B have highlighted the role of human STATs in host defense against various viruses, bacteria, and fungi. Mutations in STAT1 and STAT3 disrupt various cytokine pathways that control mucocutaneous immunity against Candida species, especially Candida albicans, and Staphylococcus species, especially Staphylococcus aureus. Here we consider inborn errors of immunity arising from mutations in either STAT1 or STAT3 that affect mucocutaneous immunity to Candida and Staphylococcus species.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Candida / immunology*
  • Candidiasis / etiology
  • Candidiasis / immunology*
  • Child
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Immunity, Mucosal / genetics
  • Immunologic Deficiency Syndromes / complications
  • Immunologic Deficiency Syndromes / genetics
  • Immunologic Deficiency Syndromes / immunology*
  • Male
  • Polyendocrinopathies, Autoimmune
  • Polymorphism, Genetic
  • Risk
  • STAT Transcription Factors / genetics
  • STAT Transcription Factors / immunology
  • Signal Transduction
  • Skin / immunology
  • Skin / microbiology
  • Skin / pathology
  • Staphylococcal Infections / etiology
  • Staphylococcal Infections / immunology*
  • Staphylococcus / immunology*
  • Young Adult

Substances

  • STAT Transcription Factors

Supplementary concepts

  • Autoimmune polyendocrinopathy syndrome, type 1