Asymmetric Stem Cell Division: Precision for Robustness

Cell Stem Cell. 2012 Oct 5;11(4):461-9. doi: 10.1016/j.stem.2012.09.003.


Asymmetric cell division (ACD) produces two daughter cells with distinct fates or characteristics. Many adult stem cells use ACD as a means of maintaining stem cell number and thus tissue homeostasis. Here, we review recent progress on ACD, discussing conservation between stem and non-stem cell systems, molecular mechanisms, and the biological meaning of ACD.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult Stem Cells / physiology*
  • Animals
  • Asymmetric Cell Division*
  • Cell Communication
  • Cell Polarity
  • Homeostasis
  • Humans
  • M Phase Cell Cycle Checkpoints