Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus

Quintessence Int. 2012 Oct;43(9):793-800.

Abstract

Objective: To determine the effectiveness of aloe vera gel in the treatment of oral lichen planus when compared with triamcinolone acetonide.

Method and materials: A randomized, double-blind, clinical trial was designed. The study sample constituted 40 patients (23 males and 17 females) who were randomly divided into two equal groups. Group A patients received aloe vera gel, while group B patients received triamcinolone acetonide.

Results: Forty patients were included in the study. Most of the sample presented with erosive (n = 18) and atrophic (n = 14) variants of oral lichen planus. When clinical signs and symptoms were observed after 8 weeks of therapy, it was determined that aloe vera gel was more effective than triamcinolone acetonide in the treatment of oral lichen planus.

Conclusion: Aloe vera gel can be considered a safe alternative treatment for oral lichen planus.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aloe*
  • Anti-Inflammatory Agents / therapeutic use*
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Gels
  • Glucocorticoids / therapeutic use
  • Humans
  • Lichen Planus, Oral / drug therapy*
  • Lichen Planus, Oral / physiopathology
  • Male
  • Phytotherapy / methods*
  • Plant Extracts / therapeutic use*
  • Triamcinolone Acetonide / therapeutic use*
  • Wound Healing / drug effects

Substances

  • Anti-Inflammatory Agents
  • Gels
  • Glucocorticoids
  • Plant Extracts
  • Triamcinolone Acetonide