The total synthesis of corallopyronin A and myxopyronin B

Angew Chem Int Ed Engl. 2012 Nov 5;51(45):11381-4. doi: 10.1002/anie.201206560. Epub 2012 Oct 8.

Abstract

Leading the way: the synthesis of natural products with new biological targets is one of the driving forces for the development of new antibiotics. The synthesis of the two secondary metabolites corallopyronin and myxopyronin have been achieved, which are prominent leads for the inhibition of bacterial RNA polymerase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA-Directed RNA Polymerases / metabolism
  • Lactones / chemical synthesis*
  • Lactones / chemistry

Substances

  • Lactones
  • corallopyronin A
  • myxopyronin B
  • DNA-Directed RNA Polymerases