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. 2014 Jan;24(1):232-48.
doi: 10.1093/cercor/bhs308. Epub 2012 Oct 4.

Meta-analytic Connectivity Modeling Reveals Differential Functional Connectivity of the Medial and Lateral Orbitofrontal Cortex

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Free PMC article

Meta-analytic Connectivity Modeling Reveals Differential Functional Connectivity of the Medial and Lateral Orbitofrontal Cortex

David H Zald et al. Cereb Cortex. .
Free PMC article

Abstract

The orbitofrontal cortex (OFC) is implicated in a broad range of behaviors and neuropsychiatric disorders. Anatomical tracing studies in nonhuman primates reveal differences in connectivity across subregions of the OFC, but data on the connectivity of the human OFC remain limited. We applied meta-analytic connectivity modeling in order to examine which brain regions are most frequently coactivated with the medial and lateral portions of the OFC in published functional neuroimaging studies. The analysis revealed a clear divergence in the pattern of connectivity for the medial OFC (mOFC) and lateral OFC (lOFC) regions. The lOFC showed coactivations with a network of prefrontal regions and areas involved in cognitive functions including language and memory. In contrast, the mOFC showed connectivity with default mode, autonomic, and limbic regions. Convergent patterns of coactivations were observed in the amygdala, hippocampus, striatum, and thalamus. A small number of regions showed connectivity specific to the anterior or posterior sectors of the OFC. Task domains involving memory, semantic processing, face processing, and reward were additionally analyzed in order to identify the different patterns of OFC functional connectivity associated with specific cognitive and affective processes. These data provide a framework for understanding the human OFC's position within widespread functional networks.

Keywords: fMRI; network; orbital frontal; ventrolateral prefrontal; ventromedial prefrontal.

Figures

Figure 1.
Figure 1.
lOFC and mOFC seed ROIs for the MACM analysis displayed on the Colin T1 MNI template. Slice numbers indicate MNI z coordinates.
Figure 2.
Figure 2.
Areas showing significant coactivation with mOFC and lOFC seed ROIs. Areas in red indicate coactivation with mOFC; areas in blue indicate coactivation with lOFC. Areas in green indicate regions with overlapping mOFC and lOFC coactivation.
Figure 3.
Figure 3.
Regions showing statistically significant differences in the frequency of coactivation between the lOFC and mOFC seed regions. The color scale reflects the magnitude of the difference with areas in green to blue showing significantly greater coactivation with the lOFC, and areas in yellow to red showing significantly greater coactivation with the mOFC.
Figure 4.
Figure 4.
Top 20 paradigm classes with reported OFC activation (A) as a percentage of all studies reporting OFC activation and (B) as a percentage of paradigm class. Asterisks indicate paradigm classes for which OFC activations occurred more frequently than predicted by chance relative to the whole-brain distribution of activations for the given paradigm.
Figure 5.
Figure 5.
Significant coactivations in analyses restricted to specific functional domains. In all cases, red shows areas coactivated with the mOFC seed region, blue with the lOFC seed region, and purple with both.

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