Nicotinamide induces male-specific body weight loss in the postnatal period through molecular regulation of the hypothalamus and liver

Neurosci Lett. 2012 Nov 21;530(2):166-71. doi: 10.1016/j.neulet.2012.09.055. Epub 2012 Oct 5.


Molecular mechanisms of body weight control have been discovered recently and much research focuses on the hypothalamic regulation of food intake and the hepatic regulation of glucose utility. We previously reported that postnatal nicotinamide treatment reduced brain dopamine and body weight. To further investigate the differential effects of nicotinamide-mediated body weight loss, nicotinamide (i.p. 100mg/kg) was injected into postnatal and adult mice twice a week for 4 weeks. Interestingly, following nicotinamide treatment, male postnatal mice displayed reduced body weight and spontaneous motor activity. No significant changes were observed in adult and postnatal female mice or adult male mice following nicotinamide treatment. In male postnatal mice, hypothalamic agouti-related peptide (AGRP) and proopiomelanocortin (POMC) levels were increased in the arcuate nucleus following nicotinamide treatment. Neuropeptide Y (NPY) levels were unchanged in both male and female mice. Additionally, nicotinamide-injected male postnatal mice had increased glucose 6-phosphatase (G6Pase) and decreased phosphoenolpyruvate carboxykinase (PEPCK) expression in liver. These results indicate that hypothalamic POMC and hepatic PEPCK are important molecules that mediate nicotinamide-induced weight loss in postnatal male mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Female
  • Glucose-6-Phosphatase / metabolism*
  • Hypothalamus / drug effects
  • Hypothalamus / physiology*
  • Liver / drug effects
  • Liver / physiology*
  • Male
  • Mice
  • Mice, Inbred ICR
  • Niacinamide / pharmacology*
  • Phosphoenolpyruvate Carboxykinase (ATP) / metabolism*
  • Pro-Opiomelanocortin / metabolism*
  • Sex Factors
  • Vitamin B Complex / pharmacology
  • Weight Loss / drug effects
  • Weight Loss / physiology*


  • Vitamin B Complex
  • Niacinamide
  • Pro-Opiomelanocortin
  • Glucose-6-Phosphatase
  • Phosphoenolpyruvate Carboxykinase (ATP)